INTRODUCTION:

MaraPine Pycnogenol® is a U.S. patented and trademarked, natural compound that is produced in its basic, generic form by Horphag Research Ltd in France. A water- processed extract from the bark of the French MaraPine tree, the compound is not a drug and not an herb.  Composed of more than forty sub-compounds, reports demonstrate that it is the most potent nutritional antioxidant discovered by science.

UNIVERSITY STUDIES

Hundreds of research studies have been published in the peer-reviewed scientific literature from dozens of Universities and research institutes around the world for the past 40 years.  However, the compound is relatively new to physicians and consumers in North America. Nevertheless due to overwhelmingly positive anecdotal clinical results individual physicians have obtained thus far, major universities in the U.S. have already begun full-scale, double-blind research studies relating to Pycnogenol®'s effectiveness for such conditions as Alzheimer’s disease and immune system dysfunctional conditions. Also, an internationally-respected Midwest psychiatric center has started a landmark research study to document the compound's efficacy for ADD/ADHD.

COMMERCIAL SOURCE OF THE COMPOUND:

The commercial source we continue to use for the compound has formulated a proprietary, blended MaraPine Pycnogenol® that has significantly greater potency, bio-availability and clinical effectiveness compared to generic Pycnogenol® sold over the counter in pharmacies and from other sources. Because MaraPine Pycnogenol® is delivered in capsules that fully disintegrate in a moist environment, all of the contents are released into the digestive system so that more Pycnogenol® can be absorbed.  In addition, homeopathic cell salts optimize how much Pycnogenol® can be absorbed and utilized by the body's cells. 

However, if you prefer to obtain the basic, generic Pycnogenol® from local pharmacies or stores keep in mind the differences in clinical effectiveness.  To achieve the same degree and speed of patient relief you may need to take as much as 3.5 to 4.5 times more if you use other brands.  You may wish to perform your own comparative trials to confirm this fact. (See the Simple Test For Comparative, Clinical Effectiveness below)

INDICATIONS:

MaraPine Pycnogenol® has been efficacious for helping patients suffering from a wide variety of health problems, particularly of the chronic degenerative type. MaraPine Pycnogenol® is becoming almost legendary for providing relief, plus nutritionally supporting and strengthening the collagen and elastin within joints and muscles. For further study on the compound (as well as more in depth safety documentation than stated below) you may obtain the book: Pycnogenol®, The Super Protector Nutrient by Richard A. Passwater, Ph.D., published by Keats Publishing. 

BASIC SAFETY INFORMATION

According to researchers at the Pasteur Institute and the Huntington Institute, MaraPine Pycnogenol® is virtually nontoxic to humans and mammals. Water-soluble, it is also non-carcinogenic, non-mutagenic, non-antigenic and non-habit forming. Consumed in Europe under medical supervision for years, it is now available in the U.S. and Canada without a prescription.

Chronic toxicity studies reveal no adverse effects in man, even from massive doses of up to 35,000 milligrams daily for more than six months. Considering that recommended usage for a 300 pound patient and at "double saturation' level would still only involve 600 milligrams per day, (as an example), this compound should be viewed as completely safe. MaraPine Pycnogenol® is classified within the same 'safe to use" class of supplemental compounds as vitamin C.

USAGE AND ADMINISTRATION:

The usage guidelines that follow are based upon the currently-recommended Utah source's formulations of MaraPine Pycnogenol®, physicians' clinical experiences with them, and the Pycnogenol® U.S. patent document filed in Washington D.C.

The compound is usually best consumed with a meal in divided amounts.  Capsule can be opened and mixed with food or beverages for children, if there is difficulty swallowing.

For relief of actual health challenges, and physical symptoms, you must follow the exact therapeutic daily recommendations shown and for the precise recovery time periods explained. Otherwise, therapeutic health results will not occur.

RATE OF SYMPTOM RELIEF:

Some people have been starting at full, daily saturation usage levels... However, we suggest a more gradual approach to Pycnogenol® usage.  If you follow our more conservative approach , do not expect to begin to experience relief of symptoms until sometime between day 10 and day 30.  Then understand that the results from Pycnogenol® generally increase gradually during another 30 to 120 days’ time.  For many who suffer long-existing, chronic conditions, six months or more are often required for maximum relief.

PHASE 1: GRADUAL INCREASE TO SATURATION

First determine your weight in pounds and divide by 25.  One capsule for each 25 pounds is your daily saturation level.  Plan a gradual increase in the number of capsules over several days, until achieving the daily saturation level.

The daily, increased increments in usage do not have to be calculated with mathematical precision. Just use roughly estimated increases from a very low amounts on day one to the full saturation level a few days later.   You must attend to what your body tells you and adjust your usage according to what your body needs. 

Although MaraPine Pycnogenol® is not toxic, it will displace environmental and metabolic toxins stored or retained in the body's fatty tissues, liver, etc, and flush them out of your body.  Because the liver, kidneys and colon need to convert and/or expel those toxins after they are released into the bloodstream, you should provide sufficient time to do so gradually. You will not want excessively large volumes of stored body toxins to be released suddenly. Thus, by gradually increasing the number of capsules you need over several days, you will avoid the "detoxification reaction" that sometimes develops when people start at the full saturation usage.

The gradual buildup to daily saturation usage prevents uncomfortable detoxification reactions from the rapid elimination of body toxins in practically all cases. However, a very rare few may still experience symptoms such as mild diarrhea, skin rash, light-headedness, slight headache, gas or stomach upset, or even feeling as though their symptoms were getting worse.

Actually a positive sign, it indicates large amounts of health-retarding toxins are being cleansed from the body. If such complaints are tolerable, maintain saturation usage level but include at least 8 to 10 eight-ounce glasses of water per day to accelerate toxins elimination. Discomfort then usually ceases within 2 or 3 days and the you will  feel energized and renewed.

If NOT TOLERABLE, simply cut back Pycnogenol® usage to very low "day 1" level. Then, very gradually build up to daily saturation usage over a 30-day period or even longer. Also maintain high water intake as explained above.

PHASE 2: MAINTAIN SATURATION LEVEL UNTIL OPTIMUM RELIEF IS ACHIEVED
(Generally 60 to 120 days but often up to SIX months or more.)

After having built up to the full, daily saturation usage, closely watch for small degrees of improvements that usually do begin during the next 30 days.  Providing that small degrees of progress or improvements have at least started to be noticeable, (which is usually the result with most people, simply continue SATURATION usage until achieving maximum relief.  However, if progress is not satisfactory, gradually increase daily usage to "DOUBLE SATURATION" over another period of several days, and temporarily maintain that usage until optimum improvements have occurred. 

PHASE 3:POSSIBLE REDUCTION IN DAILY USAGE

After you have been at the daily saturation level (or 'DOUBLE saturation") and optimized relief, you may test gradual usage reductions from week to week, toward a maintenance level, which is the least daily amount of MaraPine Pycnogenol® required to maintain maximum relief of symptoms. As you experiment with gradual reduction you will find your unique level of usage by noticing your body's response.

Finding ideal, minimum daily usage simply reduces your cost.  Realize that MaraPine Pycnogenol® is so safe to use, many physicians suggest ongoing saturation usage for disease prevention. Moreover, knowing that Pycnogenol® is complete safe, many recommend ongoing double saturation usage for serious health challenges. 

PHASE 4: MAINTENANCE

Having determined the proper daily maintenance level, continue that on an ongoing basis to help maintain health benefits. Also,  help prevent future health challenges by neutralizing corrosive free radicals within the body before they can attack and degrade its cells, organs and systems.  In a recent paper by Bruce Ames, M.D., Director of the National Institute of Environmental Health Sciences Center at the University of California at Berkeley, Dr. Ames estimates that every cell in the body sustains over 10,000"hits'each day, from free radical bombardment.

A WORD OF CAUTION:

SIMPLE TEST FOR COMPARATIVE, CLINICAL EFFECTIVENESS

Nearly ten years ago Pycnogenol® was introduced to North America. Since then, doctors have proven it to be a historically effective health-restoring compound. Due to its success, many other companies have attempted to capitalize on the health trend.  Other companies now promote compounds such as grape seed extracts (not from grape skins and grapeseeds) ... extracts from soybeans... and inferior grades of pine bark extract .... And claim they are equal to, or even more effective than MaraPine Pycnogenol®.

The doctors who have recommended how Pycnogenol® should be used most effectively have proven that those claims are simply not true. However, you should not merely accept that statement ... You can do the same, simple comparative test that physicians in the field have performed as follows: 

First obtain maximum relief and health results using the recommended Utah-supplied MaraPine Pycnogenol®. Then substitute any store-purchased Pycnogenol® brand. Or, for that matter, you may substitute any other company's highly publicized antioxidant compounds.  Your symptoms will gradually start to return after having done so. You could then increase the amount of generic Pycnogenol® used until the symptoms been relieved once again.  Then calculate the relative cost-effectiveness of the generic Pycnogenol® and MaraPine Pycnogenol®.  Then you will understand the advantage of using MaraPine Pycnogenol®.

HOW A NOTED M.D. USES Pycnogenol® FOR OVER 160 SPECIFIC HEALTH CHALLENGES:

We have here included information on only a few of the many, specific clinical applications for which MaraPine Pycnogenol® is providing extremely gratifying results. However, Dr. Gary T. Fischbach, M.D. has recently authored a remarkable reference-guide book that goes much further.  Entitled, "NATURE'S MIRACLES II An M.D.'s Experiences" his 72-page paperback includes charts and tables detailing exactly how he has successfully utilized Pycnogenol® in his practice to help restore health of patients suffering from any of more than 160 different health challenges.

Dr. Fischbach is a Doctor of Internal Medicine who -- for the past 13 years -- has conducted both a busy Family Practice and an Ophthalmology practice in a small, Southeastern town. He is a 1979 Georgetown University graduate, is an active staff member of his local hospital, and an active member of the AMA plus his state and country's medical societies.